ADEXUSDx

Salicylate Test

Research Use Only

The ADEXUSDx® Salicylate Test is an enzymatic assay used for the qualitative detection of salicylate above an established cut-off in human whole blood, plasma, or serum samples in the clinical laboratory setting as an aid for healthcare professionals in the diagnosis of salicylate overdose.

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Rapid Fingerstick Salicylate Test

Touch-to-test
Self-contained
Only one drop of blood to test
  • Specifications
  • Test Method

The ADEXUSDx® Salicylate Test is an enzymatic assay used for the qualitative detection of salicylate above an established cut-off in human whole blood, plasma, or serum samples in the clinical laboratory setting as an aid for healthcare professionals in the diagnosis of salicylate overdose. Salicylate has a direct response to the nervous system of the brain and overdoses cause hyperventilation, resulting in elimination of CO2 causing the blood to become alkaline. Aspirin (acetylsalicylic acid) is a common drug used in many formulations due to its analgesic and anti-inflammatory properties. Aspirin is quickly metabolized into salicylate after ingestion and is eliminated by conjugation with glycine and glucuronic acid.

At high therapeutic or toxic doses, the salicylate elimination half life is prolonged (15-30 hours versus 2-3 hours at low doses).

Salicylate has a direct effect on the respiratory center of the brain, with overdoses causing hyperventilation. The resulting increased elimination of CO2 causes the blood to become abnormally alkaline. The respiratory alkalosis is complicated by a metabolic acidosis, which results from an accumulation of salicylic acid and other metabolic acids in the blood. The ADEXUSDx® Salicylate Test is a rapid enzymatic assay that needs only a drop of blood, plasma, or serum and delivers results in only fifteen minutes.

The ADEXUSDx® Salicylate Test is a rapid enzymatic assay that needs only a drop of whole blood, plasma or serum. A sample is dispensed to the sample application region to fill the receiving channel. When enough sample is in the receiving channel, the sample flows by capillary action into a dry porous test strip composed of a membrane array. The sample passes through the plasma separating membrane and the membrane array contains salicylate hydroxylase which converts salicylate to a catechol in the presence of NADH. There is a reaction of the catechol at the top of the array resulting in a dark brown colour. The visible appearance of brown colour in the area of the Test Position (T) indicates that the sample contains a detectable level of salicylate. For convenience, the area at the Reference Position (R) can be used to contrast the colouration of the area at the Test Position (T).

Time to Result: 15 minutes (blood samples), 7 minutes (plasma or serum samples)
Result Window: 15-20 minutes (blood samples), 7-20 minutes (plasma or serum samples)
Storage Conditions: 4 ℃ (39℉ ) 
Operating Temperature: 4 ℃ – 30℃ (39℉ – 86℉ )
Test Shelf Life: 7 months- expiration dates printed on test pouches
Sample Type(s:): Capillary blood/whole blood/plasma/serum

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