Research Use Only
The ADEXUSDx® Salicylate Test is an enzymatic assay used for the qualitative detection of salicylate above an established cut-off in human whole blood, plasma, or serum samples in the clinical laboratory setting as an aid for healthcare professionals in the diagnosis of salicylate overdose.
The ADEXUSDx® Salicylate Test is an enzymatic assay used for the qualitative detection of salicylate above an established cut-off in human whole blood, plasma, or serum samples in the clinical laboratory setting as an aid for healthcare professionals in the diagnosis of salicylate overdose. Salicylate has a direct response to the nervous system of the brain and overdoses cause hyperventilation, resulting in elimination of CO2 causing the blood to become alkaline. Aspirin (acetylsalicylic acid) is a common drug used in many formulations due to its analgesic and anti-inflammatory properties. Aspirin is quickly metabolized into salicylate after ingestion and is eliminated by conjugation with glycine and glucuronic acid.
At high therapeutic or toxic doses, the salicylate elimination half life is prolonged (15-30 hours versus 2-3 hours at low doses).
Salicylate has a direct effect on the respiratory center of the brain, with overdoses causing hyperventilation. The resulting increased elimination of CO2 causes the blood to become abnormally alkaline. The respiratory alkalosis is complicated by a metabolic acidosis, which results from an accumulation of salicylic acid and other metabolic acids in the blood. The ADEXUSDx® Salicylate Test is a rapid enzymatic assay that needs only a drop of blood, plasma, or serum and delivers results in only fifteen minutes.
